Suspected Adverse Methylphenidate– Imipramine Interactions in Children

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Suspected Adverse Methylphenidate–  Imipramine Interactions in Children

Grob CS, Coyle JT


Two cases are presented which illustrate the dangers inherent in utilizing a polypharmacy approach in treating children with psychotropic medication. In each case, severe adverse effects, including cognitive and mood deterioration, were experienced by the child when treated with a combination of methylphenidate and imipramine. Possible mechanisms at the neurotransmitter level are described as postulated determinants for this pharmacological interaction.

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